Authors’ response: Understanding variation in disease risk

Authors’ response: Understanding variation in disease risk

that neither the exact nor the approximate solution describes cancer incidence data well, and that models incorporating cell proliferation kinetics do better. 4 Be that as it may, for any stochastic model, stochastic heterogeneity is immediately introduced if the stochastic solution is used. Inter-individual variations in susceptibility arising from variations in the rates of critical biologica...

Understanding variation in disease risk: the elusive concept of frailty

The concept of frailty plays a major role in the statistical field of survival analysis. Frailty variation refers to differences in risk between individuals which go beyond known or measured risk factors. In other words, frailty variation is unobserved heterogeneity. Although understanding frailty is of interest in its own right, the literature on survival analysis has demonstrated that existen...

Understanding variation in chronic disease outcomes.

We propose an explanation for variation in disease outcomes based on patient adaptation to the conditions of chronic disease. We develop a model of patient adaptation using the example of Type 2 diabetes mellitus and assumptions about the process entailed in transforming self-care behaviors of compliance with treatment, compliance with glucose monitoring, and patient's knowledge seeking behavio...

Author's response to reviews Title:Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) Study Authors:

Line 54: How is the variant associated with mean telomere length? Is it associated with increased/decreased length? The A allele of rs2736100 was associated with decreased telomere length. This is described in the last paragraph of the Background section. Methods Line 144: Should read “Six SNPs” rather than “Six (6) SNPs”. This error has been corrected. State whether the assumptions of the cox ...

understanding of molecular pain medicine: genetic basis of variation in pain sensation and analgesia response